Publications
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Thummel, C.S., Boulet, A.M. and Lipshitz, H. (1988) Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene, 74: 445-456.

Thummel, C.S. (1989) The Drosophila E74 promoter contains essential sequences downstream from the start site of transcription. Genes and Dev., 3: 782-792.

Burtis, K.C., Thummel, C.S., Jones, C.W., Karim, F.D. and Hogness, D.S. (1990) The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Cell, 61: 85-99.

Karim, F.D., Urness, L.D., Thummel, C.S., Klemsz, M.J., McKercher, S.R., Celada, A., Van Beveren, C., Maki, R.A., Gunther, C.V., Nye, J.A. and Graves, B.A. (1990) The ETS-domain: a new DNA binding motif that recognizes a purine-rich core DNA sequence. Genes and Dev., 4: 1451-1453.

LeMaire, M.F. and Thummel, C.S. (1990) Splicing precedes polyadenylation during Drosophila E74A transcription. Mol. Cell. Biol., 10: 6059-6063.

Thummel, C.S. (1990) Puffs and gene regulation - molecular insights into the Drosophila ecdysone regulatory hierarchy. BioEssays, 12: 1-8.

Thummel, C.S., Burtis, K.C. and Hogness, D.S. (1990) Spatial and temporal patterns of E74 transcription during Drosophila development. Cell, 61: 101-111.

Urness, L.D. and Thummel, C.S. (1990) Molecular interactions within the ecdysone regulatory hierarchy: DNA binding properties of the Drosophila ecdysone-inducible E74A protein. Cell, 63: 47-61.

Boyd, L., O'Toole, E. and Thummel, C.S. (1991) Patterns of E74A RNA and protein expression at the onset of metamorphosis in Drosophila. Development, 112: 981-995.

Karim, F.D. and Thummel, C.S. (1991) Ecdysone coordinates the timing and amounts of E74A and E74B transcription in Drosophila. Genes and Dev. 5: 1067-1079.

Andres, A.J. and Thummel, C.S. (1992) Hormones, puffs, and flies - the molecular control of metamorphosis by ecdysone. Trends in Genetics, 8: 132-138.

Chen, T., Bunting, M., Karim, F.D., and Thummel, C.S. (1992) Isolation and characterization of five Drosophila genes that encode an ets-related DNA binding domain. Dev. Biology, 151: 176-191.

Karim, F.D. and Thummel, C.S. (1992) Temporal coordination of regulatory gene expression by the steroid hormone ecdysone. EMBO J., 11: 4083-4093.

Thummel, C.S. (1992) Mechanisms of transcriptional timing in Drosophila. Science, 255: 39-40.

Thummel, C.S. and Pirrotta, V. (1992) New pCaSpeR P element vectors. Dros. Info. Serv., 71: 150.

Andres, A.J., Fletcher, J.C., Karim, F.D., and Thummel, C.S. (1993) Molecular analysis of the initiation of insect metamorphosis: A comparative study of Drosophila ecdysteroid-regulated genes. Dev. Biology, 160: 388-404.

Boyd, L. and Thummel, C.S. (1993) Selection of CUG and AUG initiator codons for Drosophila E74A translation depends on downstream sequences. Proc. Natl. Acad. Sci. USA, 90: 9164-9167.

Hurban, P. and Thummel, C.S. (1993) Isolation and characterization of fifteen ecdysone-inducible Drosophila genes reveal unexpected complexities in ecdysone regulation. Mol. Cell. Biol., 13: 7101-7111.

Karim, F.D., Guild, G.M., and Thummel, C.S. (1993) The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis. Development, 118: 977-988.

Lavorgna, G., Karim, F.D., Thummel, C.S., and Wu, C. (1993) Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis. Proc. Natl. Acad. Sci USA, 90: 3004-3008.

Stone, B.L. and Thummel, C.S. (1993) The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily. Cell, 75: 307-320.

Andres, A.J. and Thummel, C.S. (1994) Methods for quantitative analysis of transcription in larvae and prepupae. In: "Drosophila melanogaster: Practical Uses in Cell and Molecular Biology"; Methods in Cell Biology, Vol. 44, (Goldstein, L. and E. Fyrberg, eds.), Academic Press, New York, pp. 565-573.

Baehrecke, E.H., Woodard, C.T. and Thummel, C.S. (1994) Temporal differences in ecdysone-regulated gene expression at the onset of Drosophila metamorphosis. In: "Perspectives in Comparative Endocrinology" (Davey, K.G., Peter, R.E., and S.S. Tobe, eds), National Research Council of Canada, pp. 395-399.

Woodard, C.T., Baehrecke, E.H. and Thummel, C.S. (1994) A molecular mechanism for the stage-specificity of the prepupal genetic response to ecdysone. Cell, 79: 607-615.

Andres, A.J. and Thummel, C.S. (1995) The Drosophila 63F early puff contains E63-1, an ecdysone-inducible gene that encodes a novel Ca++-binding protein. Development, 121: 2667-2679.

Baehrecke, E.H. and Thummel, C.S. (1995) The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by ecdysone. Dev. Biology, 171: 85-97.

Fisk, G.J. and Thummel, C.S. (1995) Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members. Proc. Natl. Acad. Sci USA, 92: 10604-10608.

Fletcher, J.C., Burtis, K.C., Hogness, D.S. and Thummel, C.S. (1995) The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone. Development, 121: 1455-1465.

Fletcher, J.C. and Thummel, C.S. (1995) The Drosophila E74 gene is required for the proper stage- and tissue-specific transcription of ecdysone-regulated genes at the onset of metamorphosis. Development, 121: 1411-1421.

Fletcher, J.C. and Thummel, C.S. (1995) The ecdysone-inducible Broad-Complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis. Genetics, 141: 1025-1035.

Horner, M.A., Chen, T. and Thummel, C.S. (1995) Ecdysone regulation and DNA binding properties of Drosophila nuclear hormone receptor superfamily members. Dev. Biology, 168: 490-502.

Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R.M. (1995) The nuclear receptor superfamily: The second decade. Cell, 83: 835-839.

Thummel, C.S. (1995) From embryogenesis to metamorphosis – The regulation and function of Drosophila nuclear receptor superfamily members. Cell, 83: 871-877.

Urness, L.D. and Thummel, C.S. (1995) Molecular analysis of a steroid-induced regulatory hierarchy: The Drosophila E74A protein directly regulates L71-6 transcription. EMBO J, 14: 6239-6246.

Thummel, C.S. (1996) Flies on steroids – Drosophila metamorphosis and the mechanisms of steroid hormone action. Trends in Genetics, 12: 306-310.

Wright, L.G. , Chen, T., Thummel, C.S. and Guild, G.M. (1996) Molecular characterization of the 71E late puff in Drosophila melanogaster reveals a family of novel genes. J. Mol. Biol, 255: 387-400.

Fletcher, J.C., D’Avino, P.P. and Thummel, C.S. (1997) A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression. Proc. Natl. Acad. Sci USA, 94, 4582-4586.

Horner, M.A. and Thummel, C.S. (1997) Mutations in the DHR39 orphan receptor gene have no effect on viability. Dros. Info. Serv., 80: 35-37.

Jiang, C., Baehrecke, E.H. and Thummel, C.S. (1997) Steroid regulated programmed cell death during Drosophila metamorphosis. Development, 124: 4673-4683.

Lam, G., Jiang, C. and Thummel, C.S. (1997) Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis. Development, 124: 1757-1769.

Thummel, C.S. (1997) Dueling orphans - Interacting nuclear receptors coordinate Drosophila metamorphosis. BioEssays, 19: 669-672.

D’Avino, P.P. and Thummel, C.S. (1998) crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis. Development, 125: 1733-1745.

Fisk, G.J. and Thummel, C.S. (1998) The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Cell, 93: 543-555.

Hall, B.L. and Thummel, C.S. (1998) The RXR homolog Ultraspiracle is an essential component of the Drosophila ecdysone receptor. Development, 125: 4709-4717.

Broadus, J., McCabe, J.R., Endrizzi, B., Thummel, C.S., and Woodard, C.T. (1999) The Drosophila ßFTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone. Molecular Cell, 3: 143-149.

D’Avino, P. P. and Thummel, C.S. (1999) Ectopic expression systems in Drosophila. In: “Methods in Enzymology. Expression of Recombinant Genes in Eukaryotic Systems,” Vol. 306 (Abelson, J.N., Simon, M.I., eds.), Academic Press, New York, 129-142.

Lam, G., Hall, B.L., Bender, M., and Thummel, C.S. (1999) DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis. Dev. Biology, 212: 204-216.

Baker, K.D., Warren, J.T., Thummel, C.S., Gilbert, L.I., and Mangelsdorf, D.J. (2000) Transcriptional activation of the Drosophila ecdysone receptor by insect and phytoecdysteroids. Ins. Biochem. Mole. Biol., 30: 1037-1043.

D’Avino, P.P. and Thummel, C.S. (2000) The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev. Biology, 220: 211-224.

Gates, J. and Thummel, C.S. (2000) An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Genetics, 156: 1765-1776.

Jiang, C., Lamblin, A.-F., Steller, H., and Thummel, C.S. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Molecular Cell, 5: 445-455.

Kozlova, T., and Thummel, C.S. (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends in Endo. and Metab., 11: 276-280.

Lam, G., and Thummel, C.S. (2000) Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Current Biology, 10:957-963.

Lee, C.-Y., Wendel, D. P., Reid, P., Lam, G., Thummel, C.S., and Baehrecke, E.H. (2000) E93 directs steroid-triggered programmed cell death in Drosophila. Molecular Cell, 6:433-443.

Vaskova, M., Bentley, A.M., Marshall, S., Reid, P., Thummel, C.S., and Andres, A.J. (2000) Genetic analysis of the Drosophila 63F early puff: characterization of mutations in E63-1 and maggie, a putative TOM22. Genetics, 156: 229-244.

Thummel, C.S. (2001) Steroid-triggered death by autophagy. BioEssays, 23: 677-682.

Thummel, C.S. (2001) Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev. Cell, 1:453-465.

Bialecki, M., Shilton, A., Fichtenberg, C., Segraves, W.A., and Thummel, C.S. (2002) Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev. Cell, 3: 209-220.

Kozlova, T., and Thummel, C.S. (2002) Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorhosis. Development, 129: 1739-1750.

Lehmann, M., C. Jiang, Y. T. Ip and Thummel, C.S. (2002) AP-1, but not NF-kB, is required for efficient steroid-triggered cell death in Drosophila. Cell Death and Differentiation, 9: 581-590.

Thummel, C.S. (2002) Ecdysone-regulated puff genes 2000. Insect Biochemistry and Molecular Biology, 32: 113-120.

Thummel, C.S. and Chory, J. (2002) Steroid signaling in plants and insects - common themes, different pathways. Genes and Dev., 16: 3113-3129.

Baker, K.D., Shewchuk, L.M., Kozlova, T., Makishima, M., Hassell, A., Wisely, B., Caravella, J.A., Lambert, M.H., Reinking, J.L., Krause, H., Thummel, C.S., Willson, T.M. and Mangelsdorf, D.J. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell, 113: 731-742.

Bashirullah, B., Pasquinelli, A.E., Kiger, A.A., Perrimon, N., Ruvkun, G. and Thummel, C.S. (2003) Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biology, 259: 1-8.

Kozlova, T. and Thummel, C.S. (2003) Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science, 301: 1911-1914. Supplemental Material

Sullivan, A.A. and Thummel, C.S. (2003) Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development. Molecular Endocrinology 17(11):2125–2137.

Ward, R.E., Reid, P., Bashirullah, A., D’Avino, P.P. and Thummel, C.S. (2003). GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev. Biol., 256: 389-402.

Ward, R.E., Evans, J.and Thummel, C.S. (2003) Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics 165: 1397–1415.

Gates, J., Lam, G., Ortiz, J.A., Losson, R.and Thummel, C.S. (2004) rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development 131: 25-36.

Yin, Viravuth P. and Thummel, C.S. (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. PNAS 101(21): 8022-8027

Beckstead, R.B., Lam, G. and Thummel, C.S. (2005) The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biology 2005, 6: R99.1-R99.13.

King-Jones, K., Jean-Philippe C., Lam, G.and Thummel, C.S. (2005) The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila.Cell, 121(5): 773-784.

King-Jones, K. and Thummel, C.S. (2005) Nuclear receptors - a perspective from Drosophila. Nature Reviews Genetics 6: 311-323 (2005).

King-Jones, K. and Thummel, C.S. (2005) Less Steroids Make Bigger Flies. Science, 310: 630-631.

Thummel, C.S. (2005) Powered by Gas - A Ligand for a Fruit Fly Nuclear Receptor. Cell, 122(2): 151-153.

Yin, Viravuth P. and Thummel, C.S. (2005) Mechanisms of steroid-triggered programmed cell death in Drosophila. Seminars in Cell & Developmental Biology 16 (2005) 237–243.

Beckstead, R.B. and Thummel, C.S. (2006) Indicted: Worms Caught using Steroids. Cell, 124: 1137-1140.

Kirst King-Jones, Michael A. Horner, Geanette Lam, and Carl S. Thummel (2006) The DHR96 nuclear receptor regulates xenobiotic responses in
Drosophila Cell Metabolism 4: 37–48.

Laura Palanker, Aleksandar S. Necakov, Heidi M. Sampson, Ruoyu Ni, Chun Hu, Carl S. Thummel and Henry M. Krause (2006) Dynamic regulation of Drosophila nuclear receptor activity in vivo Development 133:3549-3562.

Keith D. Baker, Robert B. Beckstead, David J. Mangelsdorf, and Carl S. Thummel (2007) Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila Genes & Dev 21:450-464.

Robert B. Beckstead, Geanette Lam, Carl S. Thummel (2007) Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila Insect Biochem Mol Biol 37:570-578.