Publications

(since 2000)

2017

Click to download pdfRebecca A.S. Palu, Sophia A Praggastis, Carl S. Thummel (2017) Parental obesity leads to metabolic changes in the F2 generation in Drosophila. Molecular Metabolism

2016

Click to download pdfKyle S. McCommis, Wesley T. Hodges, Daniel K. Bricker, Dona R. Wisidagama, Vincent Compan, Marla S. Remedi, Carl S. Thummel, Brian N. Fink (2016) An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Molecular Metabolism 5:602-614.

Click to download pdfWilliam E. Barry, Carl S. Thummel (2016) The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. eLife DOI:10.7554/eLife.11183

Click to download pdfRebecca A.S. Palu and Carl S. Thummel (2016) Sir2 acts through Hepatocyte Nuclear Factor 4 to maintain insulin signaling and metabolic homeostasis in Drosophila. PLOS Genetics, DOI:10.1371/journal.pgen.1005978

2015

Click to download pdfRebecca A.S. Palu and Carl S. Thummel (2015) Linking nutrients to growth through a positive feedback loop. Developmental Cell, 35:265-266.

2014

Click to download pdfUn Na, Wendou Yu, James Cox, Daniel K. Bricker, Knut Brockmann, Jared Rutter, Carl S. Thummel and Dennis R. Winge (2014) The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metabolism, 20:253-266.

Click to download pdfJonathan G. Van Vranken, Daniel K. Bricker, Noah Dephoure, Steven P. Gygi, James E. Cox, Carl S. Thummel and Jared Rutter (2014) SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metabolism, 20:241-252.

Click to download pdfTennessen, J.M., Barry, W., Cox, J. and C.S. Thummel (2014) Methods for studying metabolism in Drosophila. Methods, 68: 105-115.

Click to download pdfSomer, R.A. and C.S. Thummel (2014) Epigenetic inheritance of metabolic state. Current Opinions in Genetics and Development, 27:43-47.

Click to download pdfTennessen, J.M., Bertagnolli, N.M., Evans, J., Sieber, M.H., Cox, J. and C.S. Thummel (2014) Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis. G3; Genes, Genomes, Genetics, 4:839-850.

Click to download pdfStefanie Marxreiter & Carl S. Thummel (2014) Will branch for food -- nutrient-dependent tracheal remodeling in Drosophila. EMBO J 33:179-180.

2013

Click to download pdfJoyti R. Misra, Geanette Lam, Carl S. Thummel (2013) Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila. Insect Biochemistry and Molecular Biology 43:1116-1124.

2012

Click to download pdfDaniel K. Bricker et al. (2012) A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans. Science 337:96-100.

Click to download pdfMatthew H. Sieber and Carl S. Thummel (2012) Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Cell Metabolism 15:122-127.

2011

Click to download pdfDaniel J. Seay and Carl S. Thummel (2011) The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila. Journal of Biological Rhythms 26:497-506.

Click to download pdfJason M. Tennessen and Carl S. Thummel (2011) Coordinating growth and maturation -- Insights from Drosophila. Current Biology 21:R750-R757.

Click to download pdfJyoti R. Misra, Michael A. Horner, Geanette Lam, and Carl S. Thummel (2011) Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes & Development 25:1795-1806.

Click to download pdfAnne-Francoise Ruaud, Geanette Lam, and Carl S. Thummel (2011) The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage. Molecular Endocrinology 25:83-91.

Click to download pdfJason M. Tennessen, Keith D. Baker, Geanette Lam, Janelle Evans, and Carl S. Thummel (2011) The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Cell Metabolism 13:139-148.

2010

Click to download pdfLei Wang, Geanette Lam, and Carl S. Thummel (2010) Med24 and Mdh2 are required for Drosophila larval salivary gland cell death. Developmental Dynamics 239:954-964.

Click to download pdfAnne-Francoise Ruaud, Geanette Lam and Carl S. Thummel (2010) The Drosophila nuclear receptors DHR3 and βFTZ-F1 control overlapping developmental responses in late embryos. Development 137:123-131.

2009

Click to download pdfMatthew H. Sieber and Carl S. Thummel (2009) The DHR96 Nuclear Receptor Controls Triacylglycerol Homeostasis in Drosophila. Cell Metabolism 10:481-490.

Click to download pdfMichael A. Horner, Keith Pardee, Suya Liu, Kirst King-Jones, Gilles Lajoie, Aled Edwards, Henry M. Krause, and Carl S. Thummel (2009) The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Genes & Development 23:2711-2716.

Click to download pdfTatiana Kozlova, Geanette Lam, and Carl S. Thummel (2009) Drosophila DHR38 Nuclear Receptor Is Required for Adult Cuticle Integrity at Eclosion. Developmental Dynamics 238:701-707.

Click to download pdfLaura Palanker, Jason M. Tennessen, Geanette Lam, and Carl S. Thummel (2009) Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation. Cell Metabolism 9:228-239.

2008

Click to download pdfLei Wang, Janelle Evans, Hillary K. Andrews, Robert B. Beckstead, Carl S. Thummel and Arash Bashirullah (2008) A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. Genetics 180:269-281.

Click to download pdfAnne-Francoise Ruaud and Carl S. Thummel (2008) Serotonin and insulin signaling team up to control growth in Drosophila. Genes & Dev. 22:1851-1855.

Click to download pdfJason M. Tennessen and Carl S. Thummel (2008) Developmental Timing: let-7 function conserved through evolution. Current Biology 18:R707.

2007

Click to download pdfKeith D. Baker, Robert B. Beckstead, David J. Mangelsdorf, and Carl S. Thummel (2007) Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Genes & Dev 21:450-464.

Click to download pdfThummel, C.S. (2007) To die or not to diea role for Forkhead. Journal of Cell Biology, Vol.176, No. 6 737-739.

Click to download pdfViravuth P. Yin, Carl S. Thummel, and Arash Bashirullah (2007) Down-regulation of Inhibitor of Apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol 178:85-92.

Click to download pdfKeith D. Baker and Carl S. Thummel (2007) Diabetic larvae and obese fliesemerging studies of metabolism in Drosophila. Cell Metabolism 6:257-266.

Click to download pdfArash Bashirullah, Geanette Lam, Viravuth P. Yin, and Carl S. Thummel (2007) dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis. Dev Dynamics 236:3173-3179.

Click to download pdfRobert B. Beckstead, Geanette Lam, Carl S. Thummel (2007) Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila Insect. Biochem Mol Biol 37:570-578.

2006

Click to download pdfBeckstead, R.B. and Thummel, C.S. (2006) Indicted: Worms Caught using Steroids. Cell, 124: 1137-1140.

Click to download pdfKirst King-Jones, Michael A. Horner, Geanette Lam, and Carl S. Thummel (2006) The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. Cell Metabolism 4: 37-48.

Click to download pdfLaura Palanker, Aleksandar S. Necakov, Heidi M. Sampson, Ruoyu Ni, Chun Hu, Carl S. Thummel and Henry M. Krause (2006) Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development 133:3549-3562.

 

2005

Click to download pdfBeckstead, R.B., Lam, G. and Thummel, C.S. (2005) The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biology 2005, 6: R99.1-R99.13.

Click to download pdfKing-Jones, K., Jean-Philippe C., Lam, G.and Thummel, C.S. (2005) The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila.Cell, 121: 773-784.

Click to download pdfKing-Jones, K. and Thummel, C.S. (2005) Nuclear receptorsa perspective from Drosophila. Nature Reviews Genetics 6: 311-323 (2005).

Click to download pdfKing-Jones, K. and Thummel, C.S. (2005) Less Steroids Make Bigger Flies. Science, 310: 630-631. 

Click to download pdfThummel, C.S. (2005) Powered by Gas - A Ligand for a Fruit Fly Nuclear Receptor. Cell, 122: 151-153.

Click to download pdfYin, Viravuth P. and Thummel, C.S. (2005) Mechanisms of steroid-triggered programmed cell death in Drosophila. Seminars in Cell & Developmental Biology 16 (2005) 237-243.

 

2004

Click to download pdfGates, J., Lam, G., Ortiz, J.A., Losson, R.and Thummel, C.S. (2004) rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development 131: 25-36.

Click to download pdfYin, Viravuth P. and Thummel, C.S. (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. PNAS 101: 8022-8027.

 

2003

Click to download pdfBaker, K.D., Shewchuk, L.M., Kozlova, T., Makishima, M., Hassell, A., Wisely, B., Caravella, J.A., Lambert, M.H., Reinking, J.L., Krause, H., Thummel, C.S., Willson, T.M. and Mangelsdorf, D.J. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell, 113: 731-742.

Click to download pdfBashirullah, B., Pasquinelli, A.E., Kiger, A.A., Perrimon, N., Ruvkun, G. and Thummel, C.S. (2003) Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biology, 259: 1-8.

Click to download pdfKozlova, T. and Thummel, C.S. (2003) Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science, 301: 1911-1914.

Click to download pdfSullivan, A.A. and Thummel, C.S. (2003) Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development. Molecular Endocrinology 17:2125-2137.

Click to download pdfWard, R.E., Reid, P., Bashirullah, A., D'Avino, P.P. and Thummel, C.S. (2003). GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev. Biol., 256: 389-402.

Click to download pdfWard, R.E., Evans, J.and Thummel, C.S. (2003) Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics 165: 1397-1415.

 

2002

Click to download pdfBialecki, M., Shilton, A., Fichtenberg, C., Segraves, W.A., and Thummel, C.S. (2002) Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev. Cell, 3: 209-220.

Click to download pdfKozlova, T., and Thummel, C.S. (2002) Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorhosis. Development, 129: 1739-1750.

Click to download pdfLehmann, M., C. Jiang, Y. T. Ip and Thummel, C.S. (2002) AP-1, but not NF-kB, is required for efficient steroid-triggered cell death in Drosophila. Cell Death and Differentiation, 9: 581-590.

Click to download pdfThummel, C.S. (2002) Ecdysone-regulated puff genes 2000. Insect Biochemistry and Molecular Biology, 32: 113-120.

Click to download pdfThummel, C.S. and Chory, J. (2002) Steroid signaling in plants and insects - common themes, different pathways. Genes and Dev., 16: 3113-3129.

 

2001

Click to download pdfThummel, C.S. (2001) Steroid-triggered death by autophagy. BioEssays, 23: 677-682.

Click to download pdfThummel, C.S. (2001) Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev. Cell, 1:453-465.

 

2000

Click to download pdfBaker, K.D., Warren, J.T., Thummel, C.S., Gilbert, L.I., and Mangelsdorf, D.J. (2000) Transcriptional activation of the Drosophila ecdysone receptor by insect and phytoecdysteroids. Ins. Biochem. Mole. Biol., 30: 1037-1043.

Click to download pdfD'Avino, P.P. and Thummel, C.S. (2000) The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev. Biology, 220: 211-224.

Click to download pdfGates, J. and Thummel, C.S. (2000) An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Genetics, 156: 1765-1776.

Click to download pdfJiang, C., Lamblin, A.-F., Steller, H., and Thummel, C.S. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Molecular Cell, 5: 445-455.

Click to download pdfKozlova, T., and Thummel, C.S. (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends in Endo. and Metab., 11: 276-280.

Click to download pdfLam, G., and Thummel, C.S. (2000) Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Current Biology, 10:957-963.

Click to download pdfLee, C.-Y., Wendel, D. P., Reid, P., Lam, G., Thummel, C.S., and Baehrecke, E.H. (2000) E93 directs steroid-triggered programmed cell death in Drosophila. Molecular Cell, 6:433-443.

Click to download pdfVaskova, M., Bentley, A.M., Marshall, S., Reid, P., Thummel, C.S., and Andres, A.J. (2000) Genetic analysis of the Drosophila 63F early puff: characterization of mutations in E63-1 and maggie, a putative TOM22. Genetics, 156: 229-244.