Publications
(since 2000)
2024
Maximilian C. Vonolfen, Fenja L. Meyer zu Altenschildesche, Hyuck-Jin Nam, ..., Geanette Lam, Carl S. Thummel, Gilles Storelli (2024) Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Cell Reports, 42, 114693
2022
Geanette Lam, Hyuck-Jin Nam, Panagiotis D. Velentzas, Eric H. Baehrecke and Carl S. Thummel (2022) Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis. Developmental Biology, 481:104-115
Geanette Lam, Katherine Beebe and Carl S. Thummel (2022) A direct-drive GFP reporter for studies of tracheal development in Drosophila. FLY 16:105-110
2021
Sophia A. Praggastis, Hyuck-Jin Nam, Myron B. Child VI, Dean M. Castillo and Carl S. Thummel (2021) Regulation of male fertility and accessory gland gene expression by the Drosophila HR39 nuclear receptor. Developmental Biology, 479:51-60
Sophia A. Praggastis, Geanette Lam, Michael A. Horner, Hyuck-Jin Nam and Carl S. Thummel (2021) The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels. Developmental Dynamics, 250:640-651
2020
Katherine Beebe, Marcy M. Robins, Edgar J. Hernandez, Geanette Lam, Michael A. Horner, and Carl S. Thummel (2020) Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis. Genes & Development, 34:1-14
C.L. Bensard, D.R. Wisidagama, K.A. Olson, J.A. Berg, N.M. Krah, J.C. Schell, S.M. Nowinski, S. Fogarty, A.J. Bott, P. Wei, K.K. Dove, J.M. Tanner, V. Panic, A. Cluntun S. Lettlova, C.S. Earl, D.F. Namnath, K. Vázquez-Arregun, C.J. Villanueva, D. Tantin, L.C. Murtaugh, K.J. Evason, G.S. Ducker, C.S. Thummel and J. Rutter (2020) Regulation of tumor initiation by the Mitochondrial Pyruvate Carrier. Cell Metabolism, 31: 284-300
2019
Wisidagama, D.R. and C.S. Thummel (2019) Regulation of Drosophila intestinal stem cell proliferation by enterocyte mitochondrial pyruvate metabolism. G3, Genes, Genomes, Genetics, 9: 3623-3630
Wisidagama, D.R., Thomas, S.M., Lam, G. and C.S. Thummel (2019) Functional analysis of Aarf Domain-Containing Kinase 1 in Drosophila melanogaster. Dev. Dynamics https://doi.org/10.1002/dvdy.66
Gilles Storelli, Hyuck-Jin Nam, Judith Simcox, Claudio J. Villanueva, Carl S. Thummel. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Dev Cell 48:200-214.
2018
Katherine Beebe and Carl S. Thummel (2018) For Intestinal Homeostasis, You Are What You Eat. Dev Cell 47:1-2.
Marxreiter, S. and C.S. Thummel (2018) Adult functions for the Drosophila DHR78 nuclear receptor. Dev Dynamics, 247: 315-322.
2017
J.C. Schell, D.R. Wisidagama, C. Bensard, H. Zhao, P. Wei, J. Tanner, A. Flores, J. Mohlman, L. Sorensen, C. Earl, K.A. Olson, R. Miao, T.C. Waller, D. Delker, P. Kanth, L. Jiang, R.J. DeBerardinis, M.P. Bronner, D.Y. Li, J. Cox, H.R. Christofk, W.E. Lowry, C.S. Thummel, J. Rutter (2017) Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nature Cell Biol., 19: 1027-1036.
James E. Cox, Carl S Thummel, and Jason M. Tennessen (2017) Metabolomic Studies in Drosophila. Genetics 206:1169-1185.
Sophia A Praggastis and Carl S. Thummel (2017) Right time, right place: the temporal regulation of developmental gene expression. Genes & Development 31:847-848.
Rebecca A.S. Palu, Sophia A Praggastis, Carl S. Thummel (2017) Parental obesity leads to metabolic changes in the F2 generation in Drosophila. Molecular Metabolism 6:631-639.
2016
Kyle S. McCommis, Wesley T. Hodges, Daniel K. Bricker, Dona R. Wisidagama, Vincent Compan, Marla S. Remedi, Carl S. Thummel, Brian N. Fink (2016) An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Molecular Metabolism 5:602-614.
William E. Barry, Carl S. Thummel (2016) The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. eLife DOI:10.7554/eLife.11183
Rebecca A.S. Palu and Carl S. Thummel (2016) Sir2 acts through Hepatocyte Nuclear Factor 4 to maintain insulin signaling and metabolic homeostasis in Drosophila. PLOS Genetics, DOI:10.1371/journal.pgen.1005978
2015
Rebecca A.S. Palu and Carl S. Thummel (2015) Linking nutrients to growth through a positive feedback loop. Developmental Cell, 35:265-266.
2014
Un Na, Wendou Yu, James Cox, Daniel K. Bricker, Knut Brockmann, Jared Rutter, Carl S. Thummel and Dennis R. Winge (2014) The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metabolism, 20:253-266.
Jonathan G. Van Vranken, Daniel K. Bricker, Noah Dephoure, Steven P. Gygi, James E. Cox, Carl S. Thummel and Jared Rutter (2014) SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metabolism, 20:241-252.
Tennessen, J.M., Barry, W., Cox, J. and C.S. Thummel (2014) Methods for studying metabolism in Drosophila. Methods, 68: 105-115.
Somer, R.A. and C.S. Thummel (2014) Epigenetic inheritance of metabolic state. Current Opinions in Genetics and Development, 27:43-47.
Tennessen, J.M., Bertagnolli, N.M., Evans, J., Sieber, M.H., Cox, J. and C.S. Thummel (2014) Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis. G3; Genes, Genomes, Genetics, 4:839-850.
Stefanie Marxreiter & Carl S. Thummel (2014) Will branch for food -- nutrient-dependent tracheal remodeling in Drosophila. EMBO J 33:179-180.
2013
Joyti R. Misra, Geanette Lam, Carl S. Thummel (2013) Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila. Insect Biochemistry and Molecular Biology 43:1116-1124.
2012
Daniel K. Bricker et al. (2012) A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans. Science 337:96-100.
Matthew H. Sieber and Carl S. Thummel (2012) Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Cell Metabolism 15:122-127.
2011
Daniel J. Seay and Carl S. Thummel (2011) The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila. Journal of Biological Rhythms 26:497-506.
Jason M. Tennessen and Carl S. Thummel (2011) Coordinating growth and maturation -- Insights from Drosophila. Current Biology 21:R750-R757.
Jyoti R. Misra, Michael A. Horner, Geanette Lam, and Carl S. Thummel (2011) Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes & Development 25:1795-1806.
Anne-Francoise Ruaud, Geanette Lam, and Carl S. Thummel (2011) The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage. Molecular Endocrinology 25:83-91.
Jason M. Tennessen, Keith D. Baker, Geanette Lam, Janelle Evans, and Carl S. Thummel (2011) The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Cell Metabolism 13:139-148.
2010
Lei Wang, Geanette Lam, and Carl S. Thummel (2010) Med24 and Mdh2 are required for Drosophila larval salivary gland cell death. Developmental Dynamics 239:954-964.
Anne-Francoise Ruaud, Geanette Lam and Carl S. Thummel (2010) The Drosophila nuclear receptors DHR3 and βFTZ-F1 control overlapping developmental responses in late embryos. Development 137:123-131.
2009
Matthew H. Sieber and Carl S. Thummel (2009) The DHR96 Nuclear Receptor Controls Triacylglycerol Homeostasis in Drosophila. Cell Metabolism 10:481-490.
Michael A. Horner, Keith Pardee, Suya Liu, Kirst King-Jones, Gilles Lajoie, Aled Edwards, Henry M. Krause, and Carl S. Thummel (2009) The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Genes & Development 23:2711-2716.
Tatiana Kozlova, Geanette Lam, and Carl S. Thummel (2009) Drosophila DHR38 Nuclear Receptor Is Required for Adult Cuticle Integrity at Eclosion. Developmental Dynamics 238:701-707.
Laura Palanker, Jason M. Tennessen, Geanette Lam, and Carl S. Thummel (2009) Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation. Cell Metabolism 9:228-239.
2008
Lei Wang, Janelle Evans, Hillary K. Andrews, Robert B. Beckstead, Carl S. Thummel and Arash Bashirullah (2008) A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. Genetics 180:269-281.
Anne-Francoise Ruaud and Carl S. Thummel (2008) Serotonin and insulin signaling team up to control growth in Drosophila. Genes & Dev. 22:1851-1855.
Jason M. Tennessen and Carl S. Thummel (2008) Developmental Timing: let-7 function conserved through evolution. Current Biology 18:R707.
2007
Keith D. Baker, Robert B. Beckstead, David J. Mangelsdorf, and Carl S. Thummel (2007) Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Genes & Dev 21:450-464.
Thummel, C.S. (2007) To die or not to die—a role for Forkhead. Journal of Cell Biology, Vol.176, No. 6 737-739.
Viravuth P. Yin, Carl S. Thummel, and Arash Bashirullah (2007) Down-regulation of Inhibitor of Apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol 178:85-92.
Keith D. Baker and Carl S. Thummel (2007) Diabetic larvae and obese flies—emerging studies of metabolism in Drosophila. Cell Metabolism 6:257-266.
Arash Bashirullah, Geanette Lam, Viravuth P. Yin, and Carl S. Thummel (2007) dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis. Dev Dynamics 236:3173-3179.
Robert B. Beckstead, Geanette Lam, Carl S. Thummel (2007) Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila Insect. Biochem Mol Biol 37:570-578.
2006
Beckstead, R.B. and Thummel, C.S. (2006) Indicted: Worms Caught using Steroids. Cell, 124: 1137-1140.
Kirst King-Jones, Michael A. Horner, Geanette Lam, and Carl S. Thummel (2006) The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. Cell Metabolism 4: 37-48.
Laura Palanker, Aleksandar S. Necakov, Heidi M. Sampson, Ruoyu Ni, Chun Hu, Carl S. Thummel and Henry M. Krause (2006) Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development 133:3549-3562.
2005
Beckstead, R.B., Lam, G. and Thummel, C.S. (2005) The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biology 2005, 6: R99.1-R99.13.
King-Jones, K., Jean-Philippe C., Lam, G.and Thummel, C.S. (2005) The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila.Cell, 121: 773-784.
King-Jones, K. and Thummel, C.S. (2005) Nuclear receptors—a perspective from Drosophila. Nature Reviews Genetics 6: 311-323 (2005).
King-Jones, K. and Thummel, C.S. (2005) Less Steroids Make Bigger Flies. Science, 310: 630-631.
Thummel, C.S. (2005) Powered by Gas - A Ligand for a Fruit Fly Nuclear Receptor. Cell, 122: 151-153.
Yin, Viravuth P. and Thummel, C.S. (2005) Mechanisms of steroid-triggered programmed cell death in Drosophila. Seminars in Cell & Developmental Biology 16 (2005) 237-243.
2004
Gates, J., Lam, G., Ortiz, J.A., Losson, R.and Thummel, C.S. (2004) rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development 131: 25-36.
Yin, Viravuth P. and Thummel, C.S. (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. PNAS 101: 8022-8027.
2003
Baker, K.D., Shewchuk, L.M., Kozlova, T., Makishima, M., Hassell, A., Wisely, B., Caravella, J.A., Lambert, M.H., Reinking, J.L., Krause, H., Thummel, C.S., Willson, T.M. and Mangelsdorf, D.J. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell, 113: 731-742.
Bashirullah, B., Pasquinelli, A.E., Kiger, A.A., Perrimon, N., Ruvkun, G. and Thummel, C.S. (2003) Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biology, 259: 1-8.
Kozlova, T. and Thummel, C.S. (2003) Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science, 301: 1911-1914.
Sullivan, A.A. and Thummel, C.S. (2003) Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development. Molecular Endocrinology 17:2125-2137.
Ward, R.E., Reid, P., Bashirullah, A., D'Avino, P.P. and Thummel, C.S. (2003). GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev. Biol., 256: 389-402.
Ward, R.E., Evans, J.and Thummel, C.S. (2003) Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics 165: 1397-1415.
2002
Bialecki, M., Shilton, A., Fichtenberg, C., Segraves, W.A., and Thummel, C.S. (2002) Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev. Cell, 3: 209-220.
Kozlova, T., and Thummel, C.S. (2002) Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorhosis. Development, 129: 1739-1750.
Lehmann, M., C. Jiang, Y. T. Ip and Thummel, C.S. (2002) AP-1, but not NF-kB, is required for efficient steroid-triggered cell death in Drosophila. Cell Death and Differentiation, 9: 581-590.
Thummel, C.S. (2002) Ecdysone-regulated puff genes 2000. Insect Biochemistry and Molecular Biology, 32: 113-120.
Thummel, C.S. and Chory, J. (2002) Steroid signaling in plants and insects - common themes, different pathways. Genes and Dev., 16: 3113-3129.
2001
Thummel, C.S. (2001) Steroid-triggered death by autophagy. BioEssays, 23: 677-682.
Thummel, C.S. (2001) Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev. Cell, 1:453-465.
2000
Baker, K.D., Warren, J.T., Thummel, C.S., Gilbert, L.I., and Mangelsdorf, D.J. (2000) Transcriptional activation of the Drosophila ecdysone receptor by insect and phytoecdysteroids. Ins. Biochem. Mole. Biol., 30: 1037-1043.
D'Avino, P.P. and Thummel, C.S. (2000) The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev. Biology, 220: 211-224.
Gates, J. and Thummel, C.S. (2000) An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Genetics, 156: 1765-1776.
Jiang, C., Lamblin, A.-F., Steller, H., and Thummel, C.S. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Molecular Cell, 5: 445-455.
Kozlova, T., and Thummel, C.S. (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends in Endo. and Metab., 11: 276-280.
Lam, G., and Thummel, C.S. (2000) Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Current Biology, 10:957-963.
Lee, C.-Y., Wendel, D. P., Reid, P., Lam, G., Thummel, C.S., and Baehrecke, E.H. (2000) E93 directs steroid-triggered programmed cell death in Drosophila. Molecular Cell, 6:433-443.
Vaskova, M., Bentley, A.M., Marshall, S., Reid, P., Thummel, C.S., and Andres, A.J. (2000) Genetic analysis of the Drosophila 63F early puff: characterization of mutations in E63-1 and maggie, a putative TOM22. Genetics, 156: 229-244.